设计一种可重复使用的胰岛素贴片泵
我们过去一年一直在开发一种可重复使用的胰岛素贴片泵，想与大家分享一些迄今为止的工程经验教训。胰岛素微剂量输送在机械上并非易事：基础输送每小时可能只有几分之一单位，而冲击剂量则涉及较大的步进变化，并且在与移动的人体连接的几天内，所有一切都必须保持在ISO公差范围内。
我们遇到了一些有趣的限制条件：
- 来自ISO 11608的剂量准确性限制（包括基础和冲击剂量）
- 皮下流体的顺应性和可变的背压
- 储液器的变形和随时间变化的压力漂移
- 低电池电压下的电机扭矩余量
- 温度变化（皮肤与环境）对流体和机械性能的影响
- 无需持续压力传感的堵塞检测
这是一种从外观上看似简单的消费类硬件，但内部却融合了流体力学、精密机械、生物相容材料、电力限制和监管要求。
如果大家对执行器选择、储液器、故障模式、材料、测试设备或监管限制等方面有兴趣，我很乐意在评论中分享更多细节。
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We’ve been working on a reusable insulin patch pump for the past year, and I wanted to share some of the engineering lessons learned so far. Insulin micro-dosing is mechanically non-trivial: basal delivery can be fractions of a unit per hour, boluses involve larger step changes, and everything has to stay within ISO tolerances while attached to a moving human body for several days.<p>Some interesting constraints we ran into:<p>- dose accuracy limits from ISO 11608 (both basal and bolus)
- fluidic compliance and variable back-pressure under skin
- reservoir deformation and head-pressure drift over time
- motor torque margins at low battery voltages
- thermal variation (skin vs ambient) affecting fluid and mechanics
- occlusion detection without continuous pressure sensing<p>It’s one of those devices that looks like simple consumer hardware from the outside, but internally mixes fluidics, precision mechanics, biocompatible materials, power constraints, and regulatory requirements.<p>Happy to share more details in the comments about actuator choices, reservoirs, failure modes, materials, test rigs, or regulatory constraints.